The Relationship Between Microalbuminuria and the Presence and Extent of Coronary Atherosclerosis

Deveci O. S., Kabakci G., Tulumen E., Okutucu S., Aksoy H., KAYA E. B., ...More

ANGIOLOGY, vol.61, no.2, pp.184-191, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 61 Issue: 2
  • Publication Date: 2010
  • Doi Number: 10.1177/0003319709340892
  • Journal Name: ANGIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.184-191
  • Hacettepe University Affiliated: Yes

Abstract

Objective: To evaluate the relationship between micro-albuminuria (MA) and the presence and extent of coronary artery disease (CAD). Methods: Four hundred and two consecutive patients were divided into 4 groups based on the presence of diabetes mellitus (DM) and MA: DM(+)/MA(+), DM(+)/MA(-), DM(-)/MA(+), and DM(-)/MA(-). Severity of CAD was assessed by the Gensini scoring system. Results: The Gensini score was 57 +/- 38.2 vs 16.5 +/- 19.5 (P < .001) in the DM(+)/MA(+) and DM(+)/MA(-) groups and 45 +/- 39.8 vs 9.9 +/- 16.6 (P < .001) in the DM(-)/MA(+) and DM(-)/MA(-) groups. Spearman correlation analysis demonstrated a positive relation between urine albumin/creatinine ratio (ACR) and extent of CAD both in the diabetic and nondiabetic patients (r = .584, P = .001; r = .545, P = .001). Microalbuminuria was found to be an independent predictor for the presence (OR for MA: 3.728; 95% CI, 1.931-7.196; P < .001) and severity of CAD ( P < .001, beta = .563). Conclusion: A strong relationship between MA and the severity of CAD was reported.