Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases


de Jesus A. A. , Hou Y., Brooks S., Malle L., Biancotto A., Huang Y., ...More

JOURNAL OF CLINICAL INVESTIGATION, vol.130, no.4, pp.1669-1682, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 130 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.1172/jci129301
  • Title of Journal : JOURNAL OF CLINICAL INVESTIGATION
  • Page Numbers: pp.1669-1682

Abstract

BACKGROUND. Undifferentiated systemic autoinflammatory diseases (USAIDs) present diagnostic and therapeutic challenges. Chronic interferon (IFN) signaling and cytokine dysregulation may identify diseases with available targeted treatments.