Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases

de Jesus, Adriana; Hou, Yangfeng; Brooks, Stephen; Malle, Louise; Biancotto, Angelique; Huang, Yan; Calvo, Katherine; Marrero, Bernadette; Moir, Susan; Oler, Andrew; Deng, Zuoming; Sanchez, Gina; Ahmed, Amina; Allenspach, Eric; Arabshahi, Bita; Behrens, Edward; Benseler, Susanne; Bezrodnik, Liliana; Bout-Tabaku, Sharon; Brescia, AnneMarie; Brown, Diane; Burnham, Jon; Soledad Caldirola, Maria; Carrasco, Ruy; Chan, Alice; Cimaz, Rolando; Dancey, Paul; Dare, Jason; DeGuzman, Marietta; Dimitriades, Victoria; Ferguson, Ian; Ferguson, Polly; Finn, Laura; Gattorno, Marco; Grom, SEZA; Hanson, Eric; Hashkes, Philip; Hedrich, Christian; Herzog, Ronit; Horneff, Gerd; Jerath, Rita; Kessler, Elizabeth; Kim, Hanna; Kingsbury, Daniel; Laxer, Ronald; Lee, Pui; Lee-Kirsch, Min; Lewandowski, Laura; Li, Suzanne; Lilleby, Vibke; Mammadova, Vafa; Moorthy, Lakshmi; Nasrullayeva, Gulnara; O'Neil, Kathleen; Onel, Karen; Ozen, SEZA; Pan, Nancy; Pillet, Pascal; Piotto, Daniela; Punaro, Marilynn; Reiff, Andreas; Reinhardt, Adam; Rider, Lisa; Rivas-Chacon, Rafael; Ronis, Tova; Roesen-Wolff, Angela; Roth, Johannes; Ruth, Natasha; Rygg, Marite; Schmeling, Heinrike; Schulert, Grant; Scott, Christiaan; Seminario, Gisella; Shulman, Andrew; Sivaraman, Vidya; Son, Mary; Stepanovskiy, Yuriy; Stringer, Elizabeth; Taber, Sara; Terreri, Maria; Tifft, Cynthia; Torgerson, Troy; Tosi, Laura; Van Royen-Kerkhof, Annet; Muskardin, Theresa; Canna, Scott; Goldbach-Mansky, Raphaela

doi:10.1172/jci129301

Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases

de Jesus A. A., Hou Y., Brooks S., Malle L., Biancotto A., Huang Y., ...More

JOURNAL OF CLINICAL INVESTIGATION, vol.130, no.4, pp.1669-1682, 2020 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 130 Issue: 4
Publication Date: 2020
Doi Number: 10.1172/jci129301
Journal Name: JOURNAL OF CLINICAL INVESTIGATION
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, CINAHL, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
Page Numbers: pp.1669-1682
Open Archive Collection: AVESIS Open Access Collection
Hacettepe University Affiliated: Yes

Abstract

BACKGROUND. Undifferentiated systemic autoinflammatory diseases (USAIDs) present diagnostic and therapeutic challenges. Chronic interferon (IFN) signaling and cytokine dysregulation may identify diseases with available targeted treatments.