Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases

de Jesus, Adriana; Hou, Yangfeng; Brooks, Stephen; Malle, Louise; Biancotto, Angelique; Huang, Yan; Calvo, Katherine; Marrero, Bernadette; Moir, Susan; Oler, Andrew; Deng, Zuoming; Sanchez, Gina; Ahmed, Amina; Allenspach, Eric; Arabshahi, Bita; Behrens, Edward; Benseler, Susanne; Bezrodnik, Liliana; Bout-Tabaku, Sharon; Brescia, AnneMarie; Brown, Diane; Burnham, Jon; Soledad Caldirola, Maria; Carrasco, Ruy; Chan, Alice; Cimaz, Rolando; Dancey, Paul; Dare, Jason; DeGuzman, Marietta; Dimitriades, Victoria; Ferguson, Ian; Ferguson, Polly; Finn, Laura; Gattorno, Marco; Grom, SEZA; Hanson, Eric; Hashkes, Philip; Hedrich, Christian; Herzog, Ronit; Horneff, Gerd; Jerath, Rita; Kessler, Elizabeth; Kim, Hanna; Kingsbury, Daniel; Laxer, Ronald; Lee, Pui; Lee-Kirsch, Min; Lewandowski, Laura; Li, Suzanne; Lilleby, Vibke; Mammadova, Vafa; Moorthy, Lakshmi; Nasrullayeva, Gulnara; O'Neil, Kathleen; Onel, Karen; Ozen, SEZA; Pan, Nancy; Pillet, Pascal; Piotto, Daniela; Punaro, Marilynn; Reiff, Andreas; Reinhardt, Adam; Rider, Lisa; Rivas-Chacon, Rafael; Ronis, Tova; Roesen-Wolff, Angela; Roth, Johannes; Ruth, Natasha; Rygg, Marite; Schmeling, Heinrike; Schulert, Grant; Scott, Christiaan; Seminario, Gisella; Shulman, Andrew; Sivaraman, Vidya; Son, Mary; Stepanovskiy, Yuriy; Stringer, Elizabeth; Taber, Sara; Terreri, Maria; Tifft, Cynthia; Torgerson, Troy; Tosi, Laura; Van Royen-Kerkhof, Annet; Muskardin, Theresa; Canna, Scott; Goldbach-Mansky, Raphaela

doi:10.1172/jci129301

Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases

de Jesus A. A. , Hou Y., Brooks S., Malle L., Biancotto A., Huang Y., ...More

JOURNAL OF CLINICAL INVESTIGATION, vol.130, no.4, pp.1669-1682, 2020 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 130 Issue: 4
Publication Date: 2020
Doi Number: 10.1172/jci129301
Title of Journal : JOURNAL OF CLINICAL INVESTIGATION
Page Numbers: pp.1669-1682

Abstract

BACKGROUND. Undifferentiated systemic autoinflammatory diseases (USAIDs) present diagnostic and therapeutic challenges. Chronic interferon (IFN) signaling and cytokine dysregulation may identify diseases with available targeted treatments.