Heritable components of the human fecal microbiome are associated with visceral fat

BEAUMONT M., Goodrich J. K. , JACKSON M. A. , Yet I. , Davenport E. R. , VİEİRA-SİLVA S., ...More

GENOME BIOLOGY, vol.17, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17
  • Publication Date: 2016
  • Doi Number: 10.1186/s13059-016-1052-7
  • Title of Journal : GENOME BIOLOGY
  • Keywords: Fecal microbiome, Obesity, Visceral fat, Heritability, Genetic association, Twins, BODY-MASS INDEX, X-RAY ABSORPTIOMETRY, GUT MICROBIOTA, ADIPOSE-TISSUE, HUMAN OBESITY, MOUSE MODEL, WEIGHT, DIET, GENE, LACTOBACILLUS


Background: Variation in the human fecal microbiota has previously been associated with body mass index (BMI). Although obesity is a global health burden, the accumulation of abdominal visceral fat is the specific cardio-metabolic disease risk factor. Here, we explore links between the fecal microbiota and abdominal adiposity using body composition as measured by dual-energy X-ray absorptiometry in a large sample of twins from the TwinsUK cohort, comparing fecal 16S rRNA diversity profiles with six adiposity measures.