Therapy of multidrug resistant human prostate tumors in the prostate of nude mice by simultaneous targeting of the epidermal growth factor receptor and vascular endothelial growth factor receptor on tumor-associated endothelial cells


Busby J. E. , Kim S., Yazici S. , Nakamura T., Kim J., He J., ...Daha Fazla

PROSTATE, cilt.66, sa.16, ss.1788-1798, 2006 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 66 Konu: 16
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1002/pros.20519
  • Dergi Adı: PROSTATE
  • Sayfa Sayıları: ss.1788-1798

Özet

BACKGROUND. Inhibiting epidermal growth factor receptor (EGF-R) and vascular endothelial growth factor receptor (VEGF-R) activation with AEE788 can decrease prostate cancer (CaP) growth/progression. We determined whether tumor cells or tumor-associated endothelial cells were the primary target by treating multidrug-resistant (MDR) CaP growing in the prostate of nude mice.