Therapy of multidrug resistant human prostate tumors in the prostate of nude mice by simultaneous targeting of the epidermal growth factor receptor and vascular endothelial growth factor receptor on tumor-associated endothelial cells

Busby J. E., Kim S., Yazici S., Nakamura T., Kim J., He J., ...More

PROSTATE, vol.66, no.16, pp.1788-1798, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 66 Issue: 16
  • Publication Date: 2006
  • Doi Number: 10.1002/pros.20519
  • Journal Name: PROSTATE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1788-1798
  • Keywords: prostate cancer, EGF-R and VEGF-R phosphorylation, antivascular therapy, chemotherapy resistant, angiogenesis, multidrug resistant, LYMPH-NODE METASTASIS, PHASE-II TRIAL, ANTIVASCULAR THERAPY, DUAL INHIBITION, LUNG-CANCER, EXPRESSION, ANGIOGENESIS, CARCINOMA, BLOCKADE, BONE
  • Hacettepe University Affiliated: Yes

Abstract

BACKGROUND. Inhibiting epidermal growth factor receptor (EGF-R) and vascular endothelial growth factor receptor (VEGF-R) activation with AEE788 can decrease prostate cancer (CaP) growth/progression. We determined whether tumor cells or tumor-associated endothelial cells were the primary target by treating multidrug-resistant (MDR) CaP growing in the prostate of nude mice.