Therapy of multidrug resistant human prostate tumors in the prostate of nude mice by simultaneous targeting of the epidermal growth factor receptor and vascular endothelial growth factor receptor on tumor-associated endothelial cells


Busby J. E. , Kim S., Yazici S. , Nakamura T., Kim J., He J., ...More

PROSTATE, vol.66, no.16, pp.1788-1798, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 66 Issue: 16
  • Publication Date: 2006
  • Doi Number: 10.1002/pros.20519
  • Title of Journal : PROSTATE
  • Page Numbers: pp.1788-1798

Abstract

BACKGROUND. Inhibiting epidermal growth factor receptor (EGF-R) and vascular endothelial growth factor receptor (VEGF-R) activation with AEE788 can decrease prostate cancer (CaP) growth/progression. We determined whether tumor cells or tumor-associated endothelial cells were the primary target by treating multidrug-resistant (MDR) CaP growing in the prostate of nude mice.