Sedative effect of Centranthus longiflorus ssp longiflorus in rats and the influence of adrenalectomy on its effect


SULEYMAN H. , Guvenalp Z., KIZILKAYA M., Demirezer L. O.

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, cilt.127, sa.8, ss.1263-1265, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 127 Konu: 8
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1248/yakushi.127.1263
  • Dergi Adı: YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
  • Sayfa Sayıları: ss.1263-1265

Özet

Sedative effect of the aqueous extract of Centranthus longiflorus ssp. longiflorus (Cle-1) on intact and adrenalectomized rats was investigated using a thiopental sleeping test to clarify the relationship of this effect on adrenal gland hormones, particularly glucocorticoids. Adrenal gland hormones were found to play an important role in inhibiting the sedative effect of the investigated drugs. It is clear, however, that these hormones are not glucocorticoids. Glucocorticoids were not responsible for shortening the sleep period.