Comparison of WHO and endometrial intraepithelial neoplasia classifications in predicting the presence of coexistent malignancy in endometrial hyperplasia

SALMAN M. C. , USUBÜTÜN A., Boynukalin K., YÜCE K.

JOURNAL OF GYNECOLOGIC ONCOLOGY, vol.21, no.2, pp.97-101, 2010 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 2
  • Publication Date: 2010
  • Doi Number: 10.3802/jgo.2010.21.2.97
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.97-101
  • Keywords: Endometrial hyperplasia, Endometrial intraepithelial neoplasia, Endometrial cancer, Coexistent cancer, CARCINOMA, DIAGNOSIS, REPRODUCIBILITY, PRECANCERS, CANCER, RISK, EIN, HISTOPATHOLOGY, MORPHOMETRY, MANAGEMENT


Objective: The most commonly used classification system for endometrial hyperplasia is the World Health Organization system which is based on subjective criteria. Another classification system is endometrial intraepithelial neoplasia (EIN) system which uses diagnostic criteria including cytological demarcation, crowded gland architecture, minimum size of 1 mm, and careful exclusion of mimics, and aims to identify a precancer or cancer. The objective of this study was to compare the two classification systems in terms of predicting the presence of a coexistent cancer in surgically treated patients.