Bisabolane type sesquiterpenes from a marine Didiscus sponge


Tasdemir D., Bugni T., Mangalindan G., Concepcion G., Harper M., Ireland D.

TURKISH JOURNAL OF CHEMISTRY, vol.27, no.2, pp.273-279, 2003 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 2
  • Publication Date: 2003
  • Title of Journal : TURKISH JOURNAL OF CHEMISTRY
  • Page Numbers: pp.273-279

Abstract

Two bisabolane type sesquiterpene phenols, (+)-curcuphenol (1) and (+)-curcudiol (2), were isolated from a Philippine marine sponge, Didiscus sp., in addition to beta-sitosterol (3) and phenethylamine (4). The structures of the metabolites were established on the basis of spectral evidence (1D- and 2D NMR [alpha](D), EIMS). (+)-Curcuphenol (1) showed cytotoxicity, which is indicative of a p53 independent mechanism.