Bisabolane type sesquiterpenes from a marine Didiscus sponge


Tasdemir D., Bugni T., Mangalindan G., Concepcion G., Harper M., Ireland D.

TURKISH JOURNAL OF CHEMISTRY, cilt.27, sa.2, ss.273-279, 2003 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 27 Konu: 2
  • Basım Tarihi: 2003
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Sayfa Sayıları: ss.273-279

Özet

Two bisabolane type sesquiterpene phenols, (+)-curcuphenol (1) and (+)-curcudiol (2), were isolated from a Philippine marine sponge, Didiscus sp., in addition to beta-sitosterol (3) and phenethylamine (4). The structures of the metabolites were established on the basis of spectral evidence (1D- and 2D NMR [alpha](D), EIMS). (+)-Curcuphenol (1) showed cytotoxicity, which is indicative of a p53 independent mechanism.