PHBHX-HA-OXG bone graft: in-vitro characterization

Arslan A. K., Alkan F.

POLYMER BULLETIN, cilt.78, sa.4, ss.1835-1849, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 78 Sayı: 4
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1007/s00289-020-03187-3
  • Dergi Adı: POLYMER BULLETIN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Chimica, Compendex, INSPEC
  • Sayfa Sayıları: ss.1835-1849
  • Anahtar Kelimeler: PHBHX-xanthan gum blend, Bone tissue engineering, Cytochrome-c level, TNF-alpha level, XANTHAN GUM, TNF-ALPHA, 3-DIMENSIONAL SCAFFOLDS, HYBRID SCAFFOLDS, CYTOCHROME-C, POLY(3-HYDROXYBUTYRATE-CO-3-HYDROXYHEXANOATE), HYDROXYAPATITE, NANOPARTICLES, GENERATION, APOPTOSIS
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Regeneration of damaged bone tissue by using degradable scaffold is the aim of bone tissue engineering. Herein, to enhance mechanical properties and osteointegration, we produced poly hydroxybutyrate-co-hexanoate (PHBHX) scaffolds containing hydroxyapatite and oxidized xanthan gum (OXG). Morphological and physicochemical properties of the scaffolds were determined. The effects of scaffolds on bone cells were investigated. When the results were evaluated, incorporation of OXG enhanced mechanical properties and swelling rate of the scaffolds. The scaffolds did not trigger of cytochrome-c release of Saos-2 cells and TNF-alpha expression of THP-1 cells. It was seen that incorporation of OXG to PHBHX scaffolds increased Saos-2 cell proliferation. As a result, the scaffolds were found to have clinical application potential.