Juvenile Hyaline Fibromatosis: A 10-year Follow-up

BALTACIOĞLU E., GÜZELDEMİR AKÇAKANAT E., Sukuroglu E., YILDIZ K., Yuva P., Aydin G., ...More

INDIAN JOURNAL OF DERMATOLOGY, vol.62, no.2, pp.210-212, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Editorial Material
  • Volume: 62 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.4103/ijd.ijd_166_16
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.210-212
  • Hacettepe University Affiliated: Yes


Juvenile hyaline fibromatosis (JHF) is a rare hereditary disease with an autosomal recessive transmission. JHF is characterized by papulonodular skin lesions, osteolytic bone lesions, flexural joint contractures, and gingival hyperplasia and usually diagnosed in infancy or early childhood. JHF is thought to be a disorder of collagen metabolism and characterized by homogenous amorphous eosinophilic material and fibrous tissue. We report the case of a 14-year-old male child with multiple papulonodular skin lesions, progressive flexion contractures of joints, and severe gingival hyperplasia, with a 10-year follow-up. Although the lesions were totally removed thrice during the last 10 years, they recurred rigorously.