Post-induction lymph node delineation in nasopharyngeal cancer: A single-center experience.

Sari S., YİĞİT E., YAZICI G., GÜLLÜ İ. H., AKSOY S., ÖZYİĞİT G., ...Daha Fazla

Head & neck, cilt.45, sa.3, ss.612-619, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 3
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1002/hed.27274
  • Dergi Adı: Head & neck
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.612-619
  • Anahtar Kelimeler: induction chemotherapy, lymph node volume, nasopharyngeal cancer, radiotherapy, target volume delineation
  • Hacettepe Üniversitesi Adresli: Evet

Özet

© 2022 Wiley Periodicals LLC.Background: We routinely delineate the gross tumor volume (GTV) for the lymph nodes (LN) based on post-induction chemotherapy (IC) MRI in nasopharyngeal carcinoma (NPC). Herein, we investigated the sufficiency of this method, particularly in high-risk LNs. Methods: Eighty-one LNs with a high-risk of clinical extranodal extension and/or ≥3-cm diameter in 58 patients were evaluated. A new GTV covering the pre-IC LN volume was delineated for each LN. Results: The median volume reduction was 72.5% for the GTV and 53.1% for the planning target volume. After a median 43 months, the overall LN local control rate was 97.5%. The 2- and 5-year LN recurrence-free survival, overall survival, and disease-free survival rate was 88.3% and 84.4%, 92.5% and 85.1%, and 86.8% and 79.2%, respectively. Conclusion: IC yields a significant reduction in nodal target volumes, and post-IC nodal volume-based radiotherapy provides excellent LC in NPC, even in high-risk LNs.