Intracranial lipomas are regarded as congenital malformations of the meninx primitiva. Here we present two patients with pericallosal lipomas extending to the thalamus. They had generalized tonic-clonic seizures. Electroencephalograms showed generalized spike-wave discharges. It is known that the thalamus is important in the formation of sleep spindles and spike-wave discharges. Thalamic involvement by lipomas may play a role in the generation of generalized spike-wave discharges and epileptogenesis in these patients.