Effect of intra-articular injection of levobupivacaine on articular cartilage and synovium in rats

Erden I. A., Altinel S., SARICAOĞLU F., ZEYBEK N. D., AKINCI S., Asan E., ...More

ANAESTHESIST, vol.61, no.5, pp.420-423, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 61 Issue: 5
  • Publication Date: 2012
  • Doi Number: 10.1007/s00101-012-2007-3
  • Journal Name: ANAESTHESIST
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.420-423
  • Keywords: Injections, intra-articular, Levobupivacaine, Anesthetics, adverse effects, Rats, Sprague-Dawley, Knee joint surgery, ARTHROSCOPIC KNEE SURGERY, BUPIVACAINE, ANALGESIA, TOXICITY, JOINT
  • Hacettepe University Affiliated: Yes


Intra-articular local anesthetics are often used for prevention of pain after arthroscopic knee surgery. However, the effect of local anesthetics other than bupivacaine on articular cartilage and synovium has not been studied. Also, complications associated with the injection of intra-articular bupivacaine have appeared in the literature. The aim of this study was to evaluate the effects of levobupivacaine on the articular cartilage and the synovium in rats.