Synthesis of Cyclopentapyridine and Thienopyridine Derivatives as Potential Calcium Channel Modulators

GÜNDÜZ, MİYASE; SAFAK, OSMAN; Kaygisiz, B.; Kosar, B.; ŞİMŞEK, RAHİME; Erol, K.; Linden, A.

doi:10.1055/s-0031-1299744

Synthesis of Cyclopentapyridine and Thienopyridine Derivatives as Potential Calcium Channel Modulators

GÜNDÜZ M. G., SAFAK C., Kaygisiz B., Kosar B. C., ŞİMŞEK R., Erol K., ...Daha Fazla

ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, cilt.62, sa.4, ss.167-175, 2012 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 62 Sayı: 4
Basım Tarihi: 2012
Doi Numarası: 10.1055/s-0031-1299744
Dergi Adı: ARZNEIMITTELFORSCHUNG-DRUG RESEARCH
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.167-175
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Hacettepe Üniversitesi Adresli: Evet

Özet

In this study, novel condensed 1,4-dihydropyridines bearing cyclopentanone (1-21) or tetrahydrothiophene-1,1-dioxide ring (22-42) with various ester substituents were synthesized via a modified Hantzsch reaction and their calcium channel modulator activities were investigated on isolated rat ileum and rat thoracic aorta. The introduction of a cyclopentanone ring fused to the 1,4-dihydropyridine nucleus and methyl, ethyl and allyl moieties to the ester group led to more active calcium modulators.