Synthesis of Cyclopentapyridine and Thienopyridine Derivatives as Potential Calcium Channel Modulators


GÜNDÜZ M. G. , SAFAK C. , Kaygisiz B., Kosar B. C. , ŞİMŞEK R. , Erol K., ...Daha Fazla

ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, cilt.62, sa.4, ss.167-175, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 62 Konu: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1055/s-0031-1299744
  • Dergi Adı: ARZNEIMITTELFORSCHUNG-DRUG RESEARCH
  • Sayfa Sayıları: ss.167-175

Özet

In this study, novel condensed 1,4-dihydropyridines bearing cyclopentanone (1-21) or tetrahydrothiophene-1,1-dioxide ring (22-42) with various ester substituents were synthesized via a modified Hantzsch reaction and their calcium channel modulator activities were investigated on isolated rat ileum and rat thoracic aorta. The introduction of a cyclopentanone ring fused to the 1,4-dihydropyridine nucleus and methyl, ethyl and allyl moieties to the ester group led to more active calcium modulators.