Synthesis of Cyclopentapyridine and Thienopyridine Derivatives as Potential Calcium Channel Modulators

GÜNDÜZ M. G. , SAFAK C. , Kaygisiz B., Kosar B. C. , ŞİMŞEK R. , Erol K., ...More

ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, vol.62, no.4, pp.167-175, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 62 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.1055/s-0031-1299744
  • Page Numbers: pp.167-175


In this study, novel condensed 1,4-dihydropyridines bearing cyclopentanone (1-21) or tetrahydrothiophene-1,1-dioxide ring (22-42) with various ester substituents were synthesized via a modified Hantzsch reaction and their calcium channel modulator activities were investigated on isolated rat ileum and rat thoracic aorta. The introduction of a cyclopentanone ring fused to the 1,4-dihydropyridine nucleus and methyl, ethyl and allyl moieties to the ester group led to more active calcium modulators.