Dihydropyrimidine dehydrogenase enzyme deficiency: Clinical and genetic assessment of prevalence in Turkish cancer patients

Celik I. , Kars A., Guc D. , Tekuzman G., Ruacan S.

CANCER INVESTIGATION, cilt.20, sa.3, ss.333-339, 2002 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 20 Konu: 3
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1081/cnv-120001178
  • Dergi Adı: CANCER INVESTIGATION
  • Sayfa Sayıları: ss.333-339

Özet

Background: Fluorouracil has been reported to induce severe side-effects in particular subjects who have deficiency in dehydropyrimidine dehyrogenase activity, the major enzyme in the catabolism of fluorouracil.