Dihydropyrimidine dehydrogenase enzyme deficiency: Clinical and genetic assessment of prevalence in Turkish cancer patients

Celik, İSMAİL; Kars, A; Guc, DİCLE; Tekuzman, G; Ruacan, S

doi:10.1081/cnv-120001178

Dihydropyrimidine dehydrogenase enzyme deficiency: Clinical and genetic assessment of prevalence in Turkish cancer patients

Celik I., Kars A., Guc D., Tekuzman G., Ruacan S.

CANCER INVESTIGATION, cilt.20, sa.3, ss.333-339, 2002 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 20 Sayı: 3
Basım Tarihi: 2002
Doi Numarası: 10.1081/cnv-120001178
Dergi Adı: CANCER INVESTIGATION
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.333-339
Hacettepe Üniversitesi Adresli: Evet

Özet

Background: Fluorouracil has been reported to induce severe side-effects in particular subjects who have deficiency in dehydropyrimidine dehyrogenase activity, the major enzyme in the catabolism of fluorouracil.