Dihydropyrimidine dehydrogenase enzyme deficiency: Clinical and genetic assessment of prevalence in Turkish cancer patients

Celik I. , Kars A., Guc D. , Tekuzman G., Ruacan S.

CANCER INVESTIGATION, vol.20, no.3, pp.333-339, 2002 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 3
  • Publication Date: 2002
  • Doi Number: 10.1081/cnv-120001178
  • Title of Journal : CANCER INVESTIGATION
  • Page Numbers: pp.333-339


Background: Fluorouracil has been reported to induce severe side-effects in particular subjects who have deficiency in dehydropyrimidine dehyrogenase activity, the major enzyme in the catabolism of fluorouracil.