Dihydropyrimidine dehydrogenase enzyme deficiency: Clinical and genetic assessment of prevalence in Turkish cancer patients

Celik I., Kars A., Guc D., Tekuzman G., Ruacan S.

CANCER INVESTIGATION, vol.20, no.3, pp.333-339, 2002 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 3
  • Publication Date: 2002
  • Doi Number: 10.1081/cnv-120001178
  • Journal Name: CANCER INVESTIGATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.333-339
  • Hacettepe University Affiliated: Yes

Abstract

Background: Fluorouracil has been reported to induce severe side-effects in particular subjects who have deficiency in dehydropyrimidine dehyrogenase activity, the major enzyme in the catabolism of fluorouracil.