Triterpene saponins from Cyclamen mirabile and their biological activities

ÇALIŞ İ., Şatana M. E., Yürüker A., Kelican P., Demirdamar R., ALAÇAM R., ...Daha Fazla

Journal of Natural Products, cilt.60, sa.3, ss.315-318, 1997 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 60 Sayı: 3
  • Basım Tarihi: 1997
  • Doi Numarası: 10.1021/np960658j
  • Dergi Adı: Journal of Natural Products
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.315-318
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Six saponins, cyclaminorin (1), deglucocyclamin (2), cyclacoumin (3), cyclamin (4), isocyclamin (5), and mirabilin (6) were isolated from the tubers of Cyclamen mirabile. Compound 6 is a new natural compound, and its structure was established as 3-{O-β-[[β-D-xylopyranosyl-(1→2)]-[β-D- glucopyranosyl-(1→6)]-β-D-glucopyranosyl-(1→4)]-[β-D-glucopyranosyl- (1→2)]-α-L-arabinopy-ranosyl}-3β,16α,28-trihydroxyolean-12-en-30-oic acid (6). The structure elucidation of this compound was accomplished using both spectral and chemical methods. Antimicrobial and uterocontractile activities of the saponins were also investigated.