Effects of Low Dose Methotrexate in Cerebral Ischemia Reperfusion Injury in Rat

BAKAR B., Kose E. A., Sari E., Sarkarati B., Atasoy P.

JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH, cilt.32, sa.3, ss.507-518, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 3
  • Basım Tarihi: 2015
  • Dergi Adı: JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.507-518
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background: During cerebral ischemia reperfusion injury, oxidative stress leads to excitotoxicity, blood brain barrier dysfunction and inflammation. This study was designed to evaluate possible protective effects of low dose methotrexate on cerebral transient ischemia reperfusion injury in rat.