Effects of Low Dose Methotrexate in Cerebral Ischemia Reperfusion Injury in Rat

BAKAR B., Kose E. A. , Sari E., Sarkarati B., Atasoy P.

JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH, vol.32, no.3, pp.507-518, 2015 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 3
  • Publication Date: 2015
  • Title of Journal : JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH
  • Page Numbers: pp.507-518

Abstract

Background: During cerebral ischemia reperfusion injury, oxidative stress leads to excitotoxicity, blood brain barrier dysfunction and inflammation. This study was designed to evaluate possible protective effects of low dose methotrexate on cerebral transient ischemia reperfusion injury in rat.