Effects of Low Dose Methotrexate in Cerebral Ischemia Reperfusion Injury in Rat

BAKAR, BÜLENT; Kose, SEVDA; Sari, Elif; Sarkarati, Bahram; Atasoy, Pinar

Effects of Low Dose Methotrexate in Cerebral Ischemia Reperfusion Injury in Rat

Atıf İçin Kopyala

BAKAR B., Kose E. A. , Sari E., Sarkarati B., Atasoy P.

JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH, cilt.32, sa.3, ss.507-518, 2015 (SCI İndekslerine Giren Dergi)

Cilt numarası: 32 Konu: 3
Basım Tarihi: 2015
Dergi Adı: JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH
Sayfa Sayıları: ss.507-518

Özet

Background: During cerebral ischemia reperfusion injury, oxidative stress leads to excitotoxicity, blood brain barrier dysfunction and inflammation. This study was designed to evaluate possible protective effects of low dose methotrexate on cerebral transient ischemia reperfusion injury in rat.