Effect of Peritoneal Lavage on TNF-alpha, IL-1 beta, and IL-6 Levels and Mortality in Intra-Abdominal Infections

KARAKOÇ D., Sayek I.

INTERNATIONAL SURGERY, vol.93, no.6, pp.346-353, 2008 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 93 Issue: 6
  • Publication Date: 2008
  • Journal Name: INTERNATIONAL SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.346-353
  • Hacettepe University Affiliated: Yes

Abstract

The mortality rate of intra-abdominal infections is high, and new prognostic factors are being investigated. Tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1 beta, and IL-6 are among these factors. Intraoperative peritoneal lavage is part of surgical treatment for intra-abdominal infection. The aim of this study is to investigate the effect of peritoneal lavage on TNF-alpha, IL-1 beta, and IL-6 levels and mortality when the source control has or has not been established. Eighty-five rats were divided into control, cecal ligation and puncture, and cecal ligation and puncture with excision groups. The effect of peritoneal lavage on TNF-alpha, IL-1 beta d, and IL-6 levels and mortality could not be shown in this study.