Effect of Peritoneal Lavage on TNF-alpha, IL-1 beta, and IL-6 Levels and Mortality in Intra-Abdominal Infections

KARAKOÇ D., Sayek I.

INTERNATIONAL SURGERY, cilt.93, sa.6, ss.346-353, 2008 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 93 Sayı: 6
  • Basım Tarihi: 2008
  • Dergi Adı: INTERNATIONAL SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.346-353
  • Hacettepe Üniversitesi Adresli: Evet

Özet

The mortality rate of intra-abdominal infections is high, and new prognostic factors are being investigated. Tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1 beta, and IL-6 are among these factors. Intraoperative peritoneal lavage is part of surgical treatment for intra-abdominal infection. The aim of this study is to investigate the effect of peritoneal lavage on TNF-alpha, IL-1 beta, and IL-6 levels and mortality when the source control has or has not been established. Eighty-five rats were divided into control, cecal ligation and puncture, and cecal ligation and puncture with excision groups. The effect of peritoneal lavage on TNF-alpha, IL-1 beta d, and IL-6 levels and mortality could not be shown in this study.