Clinical and therapeutic predictors of disease outcomes in AQP4-IgG + neuromyelitis optica spectrum disorder

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Kunchok A., Malpas C., Nytrova P., Havrdova E. K., Alroughani R., TERZİ M., ...More

MULTIPLE SCLEROSIS AND RELATED DISORDERS, vol.38, 2020 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 38
• Publication Date: 2020
• Doi Number: 10.1016/j.msard.2019.101868
• Journal Name: MULTIPLE SCLEROSIS AND RELATED DISORDERS
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
• Hacettepe University Affiliated: Yes

Abstract

Background: Aquaporin-4-IgG positive (AQP4-IgG(+)) Neuromyelitis Optica Spectrum Disorder (NMOSD) is an uncommon central nervous system autoimmune disorder. Disease outcomes in AQP4-IgG + NMOSD are typically measured by relapse rate and disability. Using the MSBase, a multi-centre international registry, we aimed to examine the impact immunosuppressive therapies and patient characteristics as predictors of disease outcome measures in AQP4-IgG + NMOSD.