The purpose of this study was to examine the complementary and alternative medicine (CAM) use in patients with rheumatoid arthritis living in different regions and cities of Turkey as well as the factors affecting the use of CAM modalities. Planned as a descriptive and cross-sectional study, this research was conducted as a study covering the rheumatology units of 10 university and 4 state hospitals in Turkey. A total of 594 patients meeting the research inclusion criteria comprised the sample. It was detected that 46.9% (n = 279) of the patients with rheumatoid arthritis whose average disease duration was 10.32 +/- 9.05 years used CAM modalities. The most common 3 modalities used by these patients were herbs taken orally, nutritional supplements, and mind-body therapies, with rates of 54.5%, 41.2%, and 40.5%, respectively. It was determined that such variables as age, sex, marital status, education status, and economic situation did not affect the use of CAM (P > .05).