Molecular Investigation of a Fungemia Outbreak Due to Candida parapsilosis in an Intensive Care Unit


DİZBAY M., Kalkanci A., Sezer B. E. , Aktas F., AYDOĞAN S. , Fidan I., ...More

BRAZILIAN JOURNAL OF INFECTIOUS DISEASES, vol.12, no.5, pp.395-399, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 5
  • Publication Date: 2008
  • Doi Number: 10.1590/s1413-86702008000500010
  • Title of Journal : BRAZILIAN JOURNAL OF INFECTIOUS DISEASES
  • Page Numbers: pp.395-399

Abstract

We investigated a nosocomial cluster of four Candida parapsilosis fungemia episodes that occurred in a neurological intensive care unit over a two-week period. The four infected patients had received parenteral nutrition through central lines, and all four had catheter-related candidemia. All of the isolates were susceptible to all of the antifungals tested, including amphotericin B, fluconazole, voriconazole, and caspofungin. They had strictly related fingerprints, based on randomly amplified polymorphic DNA analysis. Additional DNA sequencing data revealed that they were same strain. Although no isolate of Candida parapsilosis was recovered from other clinical, surveillance, or environmental samples, nosocomial spread of this yeast ceased, following the reinforcement of infection-control measures. Candida parapsilosis may require an intravascular foreign body to cause fungemia, but this outbreak shows that it can be transmitted nosocomially and can cause epidemics.