Microporous scaffolds from poly(lactide-co-epsilon-caprolactone) composites with hydroxyapatite and tricalcium phosphates using supercritical CO2 for bone tissue engineering

Aydin H. M., Piskin E., Calimli A.

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, cilt.19, sa.5, ss.383-394, 2004 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 5
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1177/0883911504046688
  • Dergi Adı: JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.383-394
  • Anahtar Kelimeler: bone tissue engineering, microporous scaffolds, biodegradable copolymers, hydroxyapatite, tricalcium phosphates, supercritical CO2, BIODEGRADABLE LACTONE COPOLYMERS, EPSILON-CAPROLACTONE, COORDINATION POLYMERIZATION, L-LACTIDE, POLYLACTONES, TRANSESTERIFICATION, POLY(L-LACTIDE), L,L-LACTIDE, BEHAVIOR
  • Hacettepe Üniversitesi Adresli: Evet

Özet

A copolymer of L-lactide and epsilon-caprolactone (M-n: 73,523, M-w: 127,990 and PI: 1.74) was synthesized by ring-opening polymerization and confirmed by FTIR, H-1-NMR and DSC. The copolymer ratio of L-lactide to epsilon-caprolactone, determined by H-1-NMR, was 89/11. Specific amounts of hydroxyapatite or tricalcium phosphate were blended in the copolymer matrix to form new composites. Films were made by solvent casting the copolymer and the composite materials. The films were subjected to supercritical CO2 at 3300 psi and 70degreesC to create porous structures. The pore sizes were in the range of 40-80 mum. The porous films (both copolymer and composite) degraded in Ringer solutions much faster than corresponding untreated nonporous films.