Impairment of thiol-disulfide homeostasis in preeclampsia

Korkmaz V., KURDOĞLU Z., Alisik M., Çetin O., Korkmaz H., Surer H., ...Daha Fazla

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, cilt.29, sa.23, ss.3848-3853, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 29 Konu: 23
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3109/14767058.2016.1149561
  • Sayfa Sayıları: ss.3848-3853


Aim: To investigate the effects of severity of preeclampsia on thiol-disulfide homeostasis (TDH).Material and methods: A total of 108 participants were divided into three groups: Group 1 was composed of pregnant women with no obstetric complications, Group 2 included pregnant women with mild preeclampsia, and Group 3 consisted of pregnant women with severe preeclampsia. TDH parameters were determined, and comparisons of clinical and routine laboratory test findings were made in all groups.Results: The serum native thiol level was 347.927.4 in the control group, 237.2 +/- 44.2 in the mild preeclampsia group, and 227.9 +/- 53.1 in the severe preeclampsia group (p<0.001). The serum total thiol level was 376.1 +/- 31.9 in the control group, 261.8 +/- 49.4 in the mild preeclampsia group, and 248.3 +/- 57.4 in the severe preeclampsia group (p<0.001). The disulfide level was 14.1 +/- 5.6 in the control group, 12.3 +/- 5.1 in the mild preeclampsia group, and 10.2 +/- 4.8 in the severe preeclampsia group (p=0.001). A significant correlation between impairment in degree of TDH and severity of preeclampsia was observed.Conclusion: TDH was impaired in women with preeclampsia, and this impairment increased with disease severity. Therefore, impaired TDH may have a role in the etiopathogenesis of the disease.