Calcium channel blockers and essential tremor

Topaktas S., ONUR M. R., DALKARA T.

European Neurology, vol.27, no.2 (, pp.114-119, 1987 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 2 (
  • Publication Date: 1987
  • Doi Number: 10.1159/000116142
  • Journal Name: European Neurology
  • Journal Indexes: Scopus
  • Page Numbers: pp.114-119
  • Hacettepe University Affiliated: Yes


Acute effects of two calcium blockers, nifedipine and verapamil, were investigated on the tremor activity of 8 patients with essential tremor and compared with those of propranolol and placebo. Following a single oral dose of 10 mg of nifedipine, tremor intensity of the patients was increased by 71.4 ± 22.6%. Nifedipine also enhanced physiological tremor in 6 healthy volunteers by 56.0 ± 21.9%. This effect of nifedipine was not correlated with the increase in heart rate or decrease in systemic blood pressure. Verapamil (80 mg) did not appreciably alter the patients' tremor activity.