PAX-2 in the Diagnosis of Primary Renal Tumors Immunohistochemical Comparison With Renal Cell Carcinoma Marker Antigen and Kidney-Specific Cadherin


Ozcan A., Zhai J., Hamilton C., Shen S. S. , Ro J. Y. , Krishnan B., ...Daha Fazla

AMERICAN JOURNAL OF CLINICAL PATHOLOGY, cilt.131, sa.3, ss.393-404, 2009 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 131 Konu: 3
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1309/ajcpm7dw0xfhdhny
  • Dergi Adı: AMERICAN JOURNAL OF CLINICAL PATHOLOGY
  • Sayfa Sayıları: ss.393-404

Özet

The diagnosis of renal cell carcinoma (RCC) remains problematic, especially in the context of metastasis or small needle biopsy specimens. The renal cell carcinoma marker (RCCM) and kidney-specific cadherin (KSC) are considered specific markers for RCC but are expressed preferentially in specific subtypes of RCC of lower grades. This study was aimed at evaluating the usefulness of PAX-2 in the diagnosis of renal tumors and comparing it with that of RCCM and KSC. Immunostaining for PAX-2, RCCM, and KSC was performed on consecutive tissue sections of 130 renal tumors.