PAX-2 in the Diagnosis of Primary Renal Tumors Immunohistochemical Comparison With Renal Cell Carcinoma Marker Antigen and Kidney-Specific Cadherin


Ozcan A., Zhai J., Hamilton C., Shen S. S. , Ro J. Y. , Krishnan B., ...More

AMERICAN JOURNAL OF CLINICAL PATHOLOGY, vol.131, no.3, pp.393-404, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 131 Issue: 3
  • Publication Date: 2009
  • Doi Number: 10.1309/ajcpm7dw0xfhdhny
  • Title of Journal : AMERICAN JOURNAL OF CLINICAL PATHOLOGY
  • Page Numbers: pp.393-404

Abstract

The diagnosis of renal cell carcinoma (RCC) remains problematic, especially in the context of metastasis or small needle biopsy specimens. The renal cell carcinoma marker (RCCM) and kidney-specific cadherin (KSC) are considered specific markers for RCC but are expressed preferentially in specific subtypes of RCC of lower grades. This study was aimed at evaluating the usefulness of PAX-2 in the diagnosis of renal tumors and comparing it with that of RCCM and KSC. Immunostaining for PAX-2, RCCM, and KSC was performed on consecutive tissue sections of 130 renal tumors.