Is prolonged infusion of piperacillin/tazobactam and meropenem in critically ill patients associated with improved pharmacokinetic/pharmacodynamic and patient outcomes? An observation from the Defining Antibiotic Levels in Intensive care unit patients (DALI) cohort

Abdul-Aziz, Mohd; Lipman, Jeffrey; AKOVA, MURAT; Bassetti, Matteo; De Waele, Jan; Dimopoulos, George; Dulhunty, Joel; Kaukonen, Kirsi-Maija; Koulenti, Despoina; Martin, Claude; Montravers, Philippe; Rello, Jordi; Rhodes, Andrew; Starr, Therese; Wallis, Steven; Roberts, Jason

doi:10.1093/jac/dkv288

Is prolonged infusion of piperacillin/tazobactam and meropenem in critically ill patients associated with improved pharmacokinetic/pharmacodynamic and patient outcomes? An observation from the Defining Antibiotic Levels in Intensive care unit patients (DALI) cohort

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Abdul-Aziz M. H., Lipman J., AKOVA M., Bassetti M., De Waele J. J., Dimopoulos G., ...More

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, vol.71, no.1, pp.196-207, 2016 (SCI-Expanded)

Publication Type: Article / Article
Volume: 71 Issue: 1
Publication Date: 2016
Doi Number: 10.1093/jac/dkv288
Journal Name: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.196-207
Hacettepe University Affiliated: Yes

Abstract

Objectives:We utilized the database of the Defining Antibiotic Levels in Intensive care unit patients (DALI) study to statistically compare the pharmacokinetic/pharmacodynamic and clinical outcomes between prolonged-infusion and intermittent-bolus dosing of piperacillin/tazobactam and meropenem in critically ill patients using inclusion criteria similar to those used in previous prospective studies.