Is prolonged infusion of piperacillin/tazobactam and meropenem in critically ill patients associated with improved pharmacokinetic/pharmacodynamic and patient outcomes? An observation from the Defining Antibiotic Levels in Intensive care unit patients (DALI) cohort


Abdul-Aziz M. H. , Lipman J., AKOVA M. , Bassetti M., De Waele J. J. , Dimopoulos G., ...More

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, vol.71, no.1, pp.196-207, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 71 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.1093/jac/dkv288
  • Title of Journal : JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
  • Page Numbers: pp.196-207

Abstract

Objectives:We utilized the database of the Defining Antibiotic Levels in Intensive care unit patients (DALI) study to statistically compare the pharmacokinetic/pharmacodynamic and clinical outcomes between prolonged-infusion and intermittent-bolus dosing of piperacillin/tazobactam and meropenem in critically ill patients using inclusion criteria similar to those used in previous prospective studies.