Is prolonged infusion of piperacillin/tazobactam and meropenem in critically ill patients associated with improved pharmacokinetic/pharmacodynamic and patient outcomes? An observation from the Defining Antibiotic Levels in Intensive care unit patients (DALI) cohort


Abdul-Aziz M. H. , Lipman J., AKOVA M. , Bassetti M., De Waele J. J. , Dimopoulos G., ...Daha Fazla

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, cilt.71, sa.1, ss.196-207, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 71 Konu: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1093/jac/dkv288
  • Dergi Adı: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
  • Sayfa Sayıları: ss.196-207

Özet

Objectives:We utilized the database of the Defining Antibiotic Levels in Intensive care unit patients (DALI) study to statistically compare the pharmacokinetic/pharmacodynamic and clinical outcomes between prolonged-infusion and intermittent-bolus dosing of piperacillin/tazobactam and meropenem in critically ill patients using inclusion criteria similar to those used in previous prospective studies.