The absorption of Tc-99m-alendronate given by rectal route in rabbits
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, cilt.13, sa.3, ss.213-220, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 13 Sayı: 3
- Basım Tarihi: 2008
- Doi Numarası: 10.1080/10837450801949509
- Dergi Adı: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.213-220
- Hacettepe Üniversitesi Adresli: Hayır
Özet
Alendronate sodium (ALD) is a bisphosphonate medication used in the treatment and prevention of osteoporosis. Absorption of ALD as oral formulation is very poor (0.5%-1%). Its bioavailability can decrease with food effect. It has some gastrointestinal adverse effects such as gastritis, gastric ulcer, and esophagitis. The aim of this study was to develop a rectal formulation of ALD as an alternative to oral route and to investigate the absorption of it by using gamma scintigraphy. For this reason, ALD was labeled with Technetium-99m (Tc-99m) by direct method. The radiochemical characterization of the Tc-99m-ALD was carried out by paper chromatography, thin layer chromatography, and electrophoresis methods.