Synthesis of novel 5-substituted phenyl-3-(p-isopropylpheny1)-1-phenylformazan and their biological activities


Sahin Yaglioglu A., ŞENÖZ H.

TURKISH JOURNAL OF CHEMISTRY, cilt.41, sa.6, ss.883-891, 2017 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 41 Konu: 6
  • Basım Tarihi: 2017
  • Doi Numarası: 10.3906/kim-1612-42
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Sayfa Sayıları: ss.883-891

Özet

Novel 1-substituted 3-(p-isopropylphenyl)-5-phenylformazans (3a-g) were synthesized and characterized by elemental analysis, H-1 NMR, and FT-IR techniques and UV-visible spectroscopy. Antiproliferative activities of 3a-g against HeLa and C6 cells were determined using the BrdU cell proliferation ELISA assay. 5-Florouracil was used as the positive control. The effects of substituents (-H, -CH3, and A) and their positions (ortho, meta, and para) on the antiproliferative activities were evaluated. The results of the assay indicate that I substituent exhibited higher activity against the cells at the meta and para positions than -CH3 and -H substituents. 3a-g exhibited both high antiproliferative activities against C6 cells and noncytotoxicity. 3a-g may be anticancer drug candidates.