Urinary HSP70 improves diagnostic accuracy for urinary tract infection in children: UTILISE study


Yilmaz A., Afonso A. C. , AKİL İ., Aksu B., ALPAY H., Atmis B., ...More

PEDIATRIC NEPHROLOGY, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2022
  • Doi Number: 10.1007/s00467-022-05664-5
  • Journal Name: PEDIATRIC NEPHROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: Children, Urinary tract infection, UTI, Heat shock proteins, HSP70, HEAT-SHOCK PROTEINS, HEAT-SHOCK-PROTEIN-70, FLUID
  • Hacettepe University Affiliated: Yes

Abstract

Background The accuracy of conventional urinalysis in diagnosing urinary tract infection (UTI) in children is limited, leading to unnecessary antibiotic exposure in a large fraction of patients. Urinary heat shock protein 70 (uHSP70) is a novel marker of acute urinary tract inflammation. We explored the added value of uHSP70 in discriminating UTI from other infections and conditions confused with UTI.