Studies on 3-diethylaminocarbonyl-1,4,5,6,7,8-hexahydroquinoline derivatives and their calcium channel antagonistic activities in vitro


Kismetli E. , Safak C., Erol K., Sirmagul B., Linden A.

ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, vol.54, no.7, pp.371-375, 2004 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 7
  • Publication Date: 2004
  • Title of Journal : ARZNEIMITTELFORSCHUNG-DRUG RESEARCH
  • Page Numbers: pp.371-375

Abstract

In this study, thirteen 2,6,6-trimethyl-3-carbamoyl-4-aryl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives were synthesized and screened for their calcium channel antagonistic activities. The hexahydroquinoline derivatives were synthesized according to Hantzsch reaction. The structures of the compounds were elucidated by IR, H-1-NMR, C-13-NMR, Distortionless Enhancement Polarization Transfer (DEPT), Correlation Spectroscopy (COSY), mass spectroscopy and elemental analyses.