Studies on 3-diethylaminocarbonyl-1,4,5,6,7,8-hexahydroquinoline derivatives and their calcium channel antagonistic activities in vitro
ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, cilt.54, sa.7, ss.371-375, 2004 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 54 Sayı: 7
- Basım Tarihi: 2004
- Dergi Adı: ARZNEIMITTELFORSCHUNG-DRUG RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.371-375
- Hacettepe Üniversitesi Adresli: Evet
Özet
In this study, thirteen 2,6,6-trimethyl-3-carbamoyl-4-aryl-5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives were synthesized and screened for their calcium channel antagonistic activities. The hexahydroquinoline derivatives were synthesized according to Hantzsch reaction. The structures of the compounds were elucidated by IR, H-1-NMR, C-13-NMR, Distortionless Enhancement Polarization Transfer (DEPT), Correlation Spectroscopy (COSY), mass spectroscopy and elemental analyses.