Primary tumor resection for initially staged IV breast cancer An emphasis on programmed death-ligand 1 expression, promoter methylation status, and survival

Erol T. , İmamoğlu N., Aydin B., Taşkiran Z., Esendağli G. , Kösemehmetoğlu K. , ...Daha Fazla

MEDICINE, cilt.98, sa.33, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier


Conventional therapy modalities for advanced breast cancer are problematic, whereas checkpoint blockade immunotherapy has been considered as a promising approach. This study aims to determine programmed death-ligand 1 (PD-L1) expression and methylation status of PD-L1 promoter in primary tumor tissue and metastatic foci of patients with stage IV breast cancer.