Primary tumor resection for initially staged IV breast cancer An emphasis on programmed death-ligand 1 expression, promoter methylation status, and survival


Erol T. , İmamoğlu N., Aydin B., Taşkiran Z., Esendağli G. , Kösemehmetoğlu K. , ...More

MEDICINE, vol.98, no.33, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 98 Issue: 33
  • Publication Date: 2019
  • Doi Number: 10.1097/md.0000000000016773
  • Title of Journal : MEDICINE

Abstract

Conventional therapy modalities for advanced breast cancer are problematic, whereas checkpoint blockade immunotherapy has been considered as a promising approach. This study aims to determine programmed death-ligand 1 (PD-L1) expression and methylation status of PD-L1 promoter in primary tumor tissue and metastatic foci of patients with stage IV breast cancer.