Deep vein trombosis is a systemic disease which can be seen in any place in the venous system and it's subject for doctors of all disciplines. Long term morbidity is the risk of post- thrornbotic syndrom development. Major concern is embolisation of the thrombus to the lung. The disease and its sequelae are among the best examples of preventable diseases. In 1856, Virchow described the major causes of deep vein thrombosis as, venous stasis hipercoagulation and intimal damage. Factors increasing venous stasis such as; long lasting immobilization, varicosities, obesity, atrial fibrilation, factors increasing hipercoagulability; factor V Leiden deficiency, homocystinuria, protein C or S deficiency, pregnancy, surgery, malignancy, hiperlipidemi and factors increasing the incidence of intimal damage; past operation, intravenous drug abuse, central venous catheter insertion are the main factors causing increased incidence of deep vein thrombosis. Clinical findings and symptoms are sometimes insufficient to diagnose a venous thromboembolic event, so some objectif tests may be needed for diagnosis. Rise factors, clinical findings, diagnostic methods, complicatons and treatment modalities of deep vein thrombosis are described in this review.