Co-expression of t(5;17) and t(8;21) in a Case of Acute Promyelocytic Leukemia: Review of the Literature


Uz B., ELİAÇIK E. , Isik A., AKSU S. , BÜYÜKAŞIK Y. , HAZNEDAROĞLU İ. C. , ...Daha Fazla

TURKISH JOURNAL OF HEMATOLOGY, cilt.30, sa.4, ss.400-404, 2013 (SCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 30 Konu: 4
  • Basım Tarihi: 2013
  • Doi Numarası: 10.4274/tjh.2012.0180
  • Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
  • Sayfa Sayıları: ss.400-404

Özet

Additional chromosomal abnormalities in acute myelogenous leukemia have been identified as one of the most important prognostic factors. Favorable chromosomal changes such as t(8;21), inv(16), and t(15;17) are associated with higher rates of complete remission and event-free survival. Translocation (15;17) characterizes acute promyelocytic leukemia (APL) (French-American-British class M3) in almost all patients. Secondary chromosomal abnormalities are also present in approximately 23%-29% of patients with newly diagnosed APL. The prognostic implications of t(8;21) and other secondary cytogenetic aberrations in APL are reviewed here. We present a 47-year-old woman diagnosed with APL whose initial cytogenetic analysis included both t(8;21) and t(15;17). The initial induction chemotherapy included 3 days of idarubicin (12 mg/m(2)/day) and daily all-trans retinoic acid (ATRA; 45 mg/m(2)/day). At the sixth week of treatment, a control bone marrow biopsy was found to be normocellular, t(15;17) bcr3 and t(8;21) were negative, and t(15;17) bcr1 fusion transcripts were reduced from 5007 (1.78525699%) copies per 1 mu g RNA to 40 (0.00062020%) with real-time quantitative polymerase chain reaction. Consolidation with 4 days of idarubicin (5 mg/m(2)/day), ATRA (45 mg/m(2)/day for 15 days), and cytarabine (1 g/m(2)/day for 4 days) was then started. However, the patient became pancytopenic and had neutropenic fever after consolidation treatment. Unfortunately, she died 3 months after the time of APL diagnosis, due to acute respiratory distress syndrome-like respiratory problems and multiorgan dysfunction requiring respiratory support and hemodialysis.