Amantadine is a dopaminergic agent with possible N-methylD-aspartate antagonist effects. Dopaminergic agents have been succesfully used for many purposes, including prophylaxis for influenza, adjunctive therapy for psychiatric diseases, treatment for Parkinson Disease, and treatment for disorders of consciousness. In this case report, amantadine infusion was started in a patient whose unconciousness could not be identified for ten days. A dramatic recovery was detected on the second day following amantadine infusion. The patient was discharged on the twenty-first treatment day with a 15 GCS score. Conclusion: Amantadine may be added to the standard therapy in comatose patients as it accelerates neurological functional recovery.