Molecular docking and ex vivo and in vitro anticholinesterase activity studies of Salvia sp and highlighted rosmarinic acid

DEMİREZER L. Ö. , GURBUZ P., KELİCEN UĞUR E. P. , BODUR M. , ÖZENVER N. , UZ A. , ...More

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.45, no.5, pp.1141-1148, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 5
  • Publication Date: 2015
  • Doi Number: 10.3906/sag-1404-42
  • Title of Journal : TURKISH JOURNAL OF MEDICAL SCIENCES
  • Page Numbers: pp.1141-1148
  • Keywords: Salvia, rosmarinic acid, acetylcholinesterase, isolated guinea pig ileum, computational screening, ALZHEIMERS-DISEASE, PARKINSONS-DISEASE, DEMENTIA THERAPY, ESSENTIAL OIL, ACETYLCHOLINESTERASE, EXTRACTS, TRIAL, SAGE

Abstract

Background/aim: To evaluate acetylcholinesterase (AChE) inhibitory activity and antioxidant capacity of the major molecule from Salvia sp., rosmarinic acid, as a drug candidate molecule for treatment of Alzheimer disease (AD).