Molecular docking and ex vivo and in vitro anticholinesterase activity studies of Salvia sp and highlighted rosmarinic acid

DEMİREZER L. Ö., GURBUZ P., KELİCEN UĞUR E. P., BODUR M., ÖZENVER N., UZ A., ...More

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.45, no.5, pp.1141-1148, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 5
  • Publication Date: 2015
  • Doi Number: 10.3906/sag-1404-42
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1141-1148
  • Keywords: Salvia, rosmarinic acid, acetylcholinesterase, isolated guinea pig ileum, computational screening, ALZHEIMERS-DISEASE, PARKINSONS-DISEASE, DEMENTIA THERAPY, ESSENTIAL OIL, ACETYLCHOLINESTERASE, EXTRACTS, TRIAL, SAGE
  • Hacettepe University Affiliated: Yes

Abstract

Background/aim: To evaluate acetylcholinesterase (AChE) inhibitory activity and antioxidant capacity of the major molecule from Salvia sp., rosmarinic acid, as a drug candidate molecule for treatment of Alzheimer disease (AD).