Molecular docking and ex vivo and in vitro anticholinesterase activity studies of Salvia sp and highlighted rosmarinic acid

DEMİREZER L. Ö., GURBUZ P., KELİCEN UĞUR E. P., BODUR M., ÖZENVER N., UZ A., ...Daha Fazla

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.45, sa.5, ss.1141-1148, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 5
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3906/sag-1404-42
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1141-1148
  • Anahtar Kelimeler: Salvia, rosmarinic acid, acetylcholinesterase, isolated guinea pig ileum, computational screening, ALZHEIMERS-DISEASE, PARKINSONS-DISEASE, DEMENTIA THERAPY, ESSENTIAL OIL, ACETYLCHOLINESTERASE, EXTRACTS, TRIAL, SAGE
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Background/aim: To evaluate acetylcholinesterase (AChE) inhibitory activity and antioxidant capacity of the major molecule from Salvia sp., rosmarinic acid, as a drug candidate molecule for treatment of Alzheimer disease (AD).