Direct formation of nanospheres from amphiphilic beta-cyclodextrin inclusion complexes

Memisoglu E., Bochot A., Ozalp M., ŞEN M., Duchene D., Hincal A.

PHARMACEUTICAL RESEARCH, cilt.20, sa.1, ss.117-125, 2003 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 1
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1023/a:1022263111961
  • Dergi Adı: PHARMACEUTICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.117-125
  • Anahtar Kelimeler: amphiphilic beta-cyclodextrins, inclusion complexes, nanospheres, bifonazole, clotrimazole, loading, release, hemolysis, minimum inhibitory concentration, CLOTRIMAZOLE, DERIVATIVES, BIFONAZOLE, CARRIER
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Purpose. The aim of this work was to develop and characterize a highly loaded nanoparticulate system based on amphiphilic beta-cyclodextrins (CDs) to facilitate the parenteral administration of poorly soluble antifungal model drugs bifonazole and clotrimazole.