Direct formation of nanospheres from amphiphilic beta-cyclodextrin inclusion complexes

Memisoglu E., Bochot A., Ozalp M., ŞEN M., Duchene D., Hincal A.

PHARMACEUTICAL RESEARCH, vol.20, no.1, pp.117-125, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 1
  • Publication Date: 2003
  • Doi Number: 10.1023/a:1022263111961
  • Journal Name: PHARMACEUTICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.117-125
  • Keywords: amphiphilic beta-cyclodextrins, inclusion complexes, nanospheres, bifonazole, clotrimazole, loading, release, hemolysis, minimum inhibitory concentration, CLOTRIMAZOLE, DERIVATIVES, BIFONAZOLE, CARRIER
  • Hacettepe University Affiliated: Yes

Abstract

Purpose. The aim of this work was to develop and characterize a highly loaded nanoparticulate system based on amphiphilic beta-cyclodextrins (CDs) to facilitate the parenteral administration of poorly soluble antifungal model drugs bifonazole and clotrimazole.