Direct formation of nanospheres from amphiphilic beta-cyclodextrin inclusion complexes

Memisoglu, E; Bochot, A; Ozalp, M; ŞEN, MURAT; Duchene, D; Hincal, AA

doi:10.1023/a:1022263111961

Direct formation of nanospheres from amphiphilic beta-cyclodextrin inclusion complexes

Memisoglu E., Bochot A., Ozalp M., ŞEN M., Duchene D., Hincal A.

PHARMACEUTICAL RESEARCH, vol.20, no.1, pp.117-125, 2003 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 20 Issue: 1
Publication Date: 2003
Doi Number: 10.1023/a:1022263111961
Journal Name: PHARMACEUTICAL RESEARCH
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.117-125
Keywords: amphiphilic beta-cyclodextrins, inclusion complexes, nanospheres, bifonazole, clotrimazole, loading, release, hemolysis, minimum inhibitory concentration, CLOTRIMAZOLE, DERIVATIVES, BIFONAZOLE, CARRIER
Hacettepe University Affiliated: Yes

Abstract

Purpose. The aim of this work was to develop and characterize a highly loaded nanoparticulate system based on amphiphilic beta-cyclodextrins (CDs) to facilitate the parenteral administration of poorly soluble antifungal model drugs bifonazole and clotrimazole.