Amanicadol, a pimarane-type diterpene from Phlomis amanica Vierch.


Yalcin F. N. , Ersoz T. , Bedir E., Donmez A. A. , Stavri M., Zloh M., ...Daha Fazla

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, cilt.61, sa.11, ss.1433-1436, 2006 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 61 Konu: 11
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1515/znb-2006-1118
  • Dergi Adı: ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES
  • Sayfa Sayıları: ss.1433-1436

Özet

Fractionation of the methanol extract of Phlomis amanica resulted in the isolation of a new pimarane type diterpene, amanicadol (1), together with the known glycosides lamiide, verbascoside (= acteoside), syringaresinol-4-O-beta-glucoside, liriodendrin, syringin, and a caffeic acid ester, chlorogenic acid. The structure of the new compound was established on the basis of extensive 1D and 2D NMR spectroscopic data interpretation. Molecular modeling studies on 1 were conducted and showed that it exhibited low conformational flexibility. Additionally, NMR chemical shifts were calculated for 1 in vacuo, and calculated values were in very close agreement with those found experimentally.