Effects of prenatal and lactational bisphenol a and/or di(2-ethylhexyl) phthalate exposure on male reproductive system

BALCI A., Ozkemahli G., Erkekoglu P., Zeybek D., YERSAL N., Kocer-Gumusel B.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH, cilt.32, sa.4, ss.902-915, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 4
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1080/09603123.2020.1805416
  • Dergi Adı: INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Agricultural & Environmental Science Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, CINAHL, Educational research abstracts (ERA), EMBASE, Environment Index, Food Science & Technology Abstracts, Geobase, MEDLINE, Pollution Abstracts, Veterinary Science Database
  • Sayfa Sayıları: ss.902-915
  • Anahtar Kelimeler: Bisphenol A, endocrine disruptors, phthalate, reproductive system, ENDOCRINE DISRUPTING CHEMICALS, IN-UTERO EXPOSURE, OXIDATIVE STRESS, METABOLITES, BIOMARKERS, LIFE, ASSOCIATION, APOPTOSIS, DISEASE, VITRO
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Bisphenol A (BPA) and phthalates are abundantly used endocrine disrupting chemicals (EDCs). The aim of this study was to evaluate the effects of single and combined exposures to BPA and/or di(2-ethylhexyl) phthalate (DEHP) in prenatal and lactational period on rat male reproductive system in later stages of life. Pregnant Sprague-Dawley rats were divided randomly to four groups (n= 3/group): Control (corn oil); DEHP (30 mg/kg/day); BPA (50 mg/kg/day); and BPA+ DEHP (30 mg/kg/day DEHP and 50 mg/kg/day BPA). Groups exposed to EDCs through 6-21 gestational days and lactation period by intragastric lavage. Male offspring (n= 6/group) from each mother were fed till adulthood and were then euthanized. Later, reproductive hormones, sperm parameters, and oxidative stress parameters were determined. In conclusion, we can suggest that prenatal and lactational exposure to BPA and DEHP may cause adverse effects in male reproductive system in later stages of life especially after combined exposure.