Evaluation of bioactivities of chlorokojic acid derivatives against dermatophytes couplet with cytotoxicity

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AYTEMİR M., Ozcelik B., Karakaya G.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol.23, no.12, pp.3646-3649, 2013 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 23 Issue: 12
• Publication Date: 2013
• Doi Number: 10.1016/j.bmcl.2013.03.098
• Journal Name: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.3646-3649
• Hacettepe University Affiliated: Yes

Abstract

In an attempt to find novel antifungal agents with improved activity, a series of compounds bearing 6-chloromethyl-3-hydroxy-2-substituted 4H-pyran-4-one moiety were synthesized and examined for their cytotoxic evaluation and antifungal activities against both standard and isolated dermatophytic fungal species Microsporum gypseum, Trichophyton mentagrophytes var. erinacei and Epidermophyton floccosum. (C) 2013 Elsevier Ltd. All rights reserved.