Evaluation of bioactivities of chlorokojic acid derivatives against dermatophytes couplet with cytotoxicity


AYTEMİR M. , Ozcelik B., Karakaya G.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol.23, no.12, pp.3646-3649, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 12
  • Publication Date: 2013
  • Doi Number: 10.1016/j.bmcl.2013.03.098
  • Title of Journal : BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  • Page Numbers: pp.3646-3649

Abstract

In an attempt to find novel antifungal agents with improved activity, a series of compounds bearing 6-chloromethyl-3-hydroxy-2-substituted 4H-pyran-4-one moiety were synthesized and examined for their cytotoxic evaluation and antifungal activities against both standard and isolated dermatophytic fungal species Microsporum gypseum, Trichophyton mentagrophytes var. erinacei and Epidermophyton floccosum. (C) 2013 Elsevier Ltd. All rights reserved.