CDH12 as a Candidate Gene for Kidney Injury in Posterior Urethral Valve Cases: A Genome-wide Association Study Among Patients with Obstructive Uropathies


van der Zanden L. F. M. , van Rooij I. A. L. M. , Quaedackers J. S. L. T. , Nijman R. J. M. , Steffens M., de Wall L. L. L. , ...More

EUROPEAN UROLOGY OPEN SCIENCE, vol.28, pp.26-35, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28
  • Publication Date: 2021
  • Doi Number: 10.1016/j.euros.2021.04.001
  • Title of Journal : EUROPEAN UROLOGY OPEN SCIENCE
  • Page Numbers: pp.26-35

Abstract

Background: Posterior urethral valves (PUVs) and ureteropelvic junction obstruction (UPJO) are congenital obstructive uropathies that may impair kidney development. Objective: To identify genetic variants associated with kidney injury in patients with obstructive uropathy. Design, setting, and participants: We included 487 patients born in 1981 or later who underwent pyeloplasty or valve resection before 18 yr of age in the discovery phase, 102 PUV patients in a first replication phase, and 102 in a second replication phase.