Evaluation of maternal serum folate, vitamin B12, and homocysteine levels and factor V Leiden, factor II g.20210G > A, and MTHFR variations in prenatally diagnosed neural tube defects

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Aydin H., Arisoy R., Karaman A., Erdogdu E., Cetinkaya A., Geçkinli B. B., ...More

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.46, no.2, pp.489-494, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.3906/sag-1502-128
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.489-494
  • Hacettepe University Affiliated: Yes

Abstract

Background/aim: Neural tube defects (NTDs) are common congenital malformations that develop as a result of interactions between several genes and environmental factors. Many factors have been investigated in order to understand the etiology of NTDs, and many studies have identified folate intake as a common contributing factor. The exact etiology of the disease is still unknown.