Research Information System
Other, pp.463-472, 2018
Two novel, economic, rapid, simple, sensitive and selective square wave voltammetric (SWV)
methods have been developed for the determination of cefuroxime axetil (CEFA) in pharmaceutical preparations.
Electrochemical reduction and oxidation of the substance on hanging mercury drop electrode and
graphene oxide modified glassy carbon electrode were investigated by square wave voltammetric methods
which employ scan rates up to 1000 mV/s or faster, allowing much faster determinations. For hanging mercury
drop electrode, well-defined peak was obtained at –1.06 V vs. Ag/AgCl/4.6 M KCl in 0.1 M phosphateborate
buffer pH 7.0, limit of detection (LOD), limit of quantification (LOQ) and linearity range were found
0.09, 0.26, and 0.26–15 μg mL–1, respectively. For modified glassy carbon electrode, well-defined peak was
obtained at 1.30 V vs. Ag/AgCl/4.6 M KCl in Britton–Robinson buffer pH 2.0, LOD, LOQ and linearity
range were found 2.70, 8.20, and 8.20–45 μg mL–1, respectively. According to validation studies, the developed
SWV methods were found as accurate, precise, specific, sensitive, repeatable, rugged and robust. The
developed and validated SWV methods were applied to the determination of CEFA in pharmaceutical formulations.
The results were compared with those obtained by a published ultraviolet spectroscopic method and
no difference was found statistically.