Angiotensin-converting enzyme for noninvasive assessment of liver fibrosis in autoimmune hepatitis

Efe, Cumali; Cengiz, MUSTAFA; Kahramanoglu-Aksoy, Evrim; YILMAZ, BÜLENT; Ozseker, Burak; Beyazit, Yavuz; Tanoglu, Alpaslan; PÜRNAK, TUĞRUL; KAV, TAYLAN; Turhan, Turan; Ozenirler, Seren; Ozaslan, Ersan; Wahlin, Staffan

doi:10.1097/meg.0000000000000355

Angiotensin-converting enzyme for noninvasive assessment of liver fibrosis in autoimmune hepatitis

Efe C., Cengiz M., Kahramanoglu-Aksoy E., YILMAZ B., Ozseker B., Beyazit Y., ...Daha Fazla

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, cilt.27, sa.6, ss.649-654, 2015 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 27 Sayı: 6
Basım Tarihi: 2015
Doi Numarası: 10.1097/meg.0000000000000355
Dergi Adı: EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.649-654
Hacettepe Üniversitesi Adresli: Evet

Özet

Background and aim There are no validated noninvasive markers of liver fibrosis in autoimmune hepatitis (AIH). An activated renin-angiotensin system (RAS) and its key element angiotensin-converting enzyme (ACE) have been implicated in the pathogenesis of hepatic fibrogenesis. We aimed to study the assumed role of activated RAS in the fibrogenic process and whether the serum concentration of ACE can predict different fibrosis stages in AIH.