Can Hyaluronidase Be an Alternative Postoperative Anti-edema Agent to Dexamethasone? Preliminary Results of an Animal Study

KOÇ O., ER N.

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, cilt.76, sa.8, ss.1653-1659, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 76 Sayı: 8
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.joms.2018.03.010
  • Dergi Adı: JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1653-1659
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Purpose: Recombinant human hyaluronidase (rHuPH20) is widely used as a spreading factor, which enhances the absorption of subcutaneously injected medicines. The anti-inflammatory and anti-edema effects of the enzyme were demonstrated in previous studies. In the present study, the anti-edema effect of rHuPH20 was compared with that of dexamethasone in a traumatic rat paw edema model.