Can Hyaluronidase Be an Alternative Postoperative Anti-edema Agent to Dexamethasone? Preliminary Results of an Animal Study


KOÇ O., ER N.

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, vol.76, no.8, pp.1653-1659, 2018 (SCI-Expanded) identifier identifier identifier

Abstract

Purpose: Recombinant human hyaluronidase (rHuPH20) is widely used as a spreading factor, which enhances the absorption of subcutaneously injected medicines. The anti-inflammatory and anti-edema effects of the enzyme were demonstrated in previous studies. In the present study, the anti-edema effect of rHuPH20 was compared with that of dexamethasone in a traumatic rat paw edema model.