Can Hyaluronidase Be an Alternative Postoperative Anti-edema Agent to Dexamethasone? Preliminary Results of an Animal Study


KOÇ O. , ER N.

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, vol.76, no.8, pp.1653-1659, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 76 Issue: 8
  • Publication Date: 2018
  • Doi Number: 10.1016/j.joms.2018.03.010
  • Title of Journal : JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
  • Page Numbers: pp.1653-1659

Abstract

Purpose: Recombinant human hyaluronidase (rHuPH20) is widely used as a spreading factor, which enhances the absorption of subcutaneously injected medicines. The anti-inflammatory and anti-edema effects of the enzyme were demonstrated in previous studies. In the present study, the anti-edema effect of rHuPH20 was compared with that of dexamethasone in a traumatic rat paw edema model.