Mexiletine treatment-induced inhibition of caspase-3 activation and improvement of behavioral recovery after spinal cord injury

Kaptanoglu E., Caner H., Solaroglu I., Kilinc K.

JOURNAL OF NEUROSURGERY-SPINE, vol.3, no.1, pp.53-56, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 3 Issue: 1
  • Publication Date: 2005
  • Doi Number: 10.3171/spi.2005.3.1.0053
  • Journal Name: JOURNAL OF NEUROSURGERY-SPINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.53-56
  • Hacettepe University Affiliated: No

Abstract

Object. It has been demonstrated in several experimental studies that apoptosis contributes to cellular damage after spinal cord injury (SCI). During apoptosis dying cells secrete additional mediators of apoptosis such as cytokines and free radicals which have additional toxic effects and exacerbate neuronal death. The aim of this laboratory study was to investigate the effects of mexiletine on caspase-3 activation and functional recovery and compare its post-SCI effectiveness with methylprednisolone.