Chronic L-DOPA treatment increases striatal cannabinoid CB1 receptor mRNA expression in 6-hydroxydopamine-lesioned rats

Zeng B., Dass B., Owen A., Rose S., Cannizzaro C., Tel B. C. , ...Daha Fazla

NEUROSCIENCE LETTERS, cilt.276, sa.2, ss.71-74, 1999 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 276 Konu: 2
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1016/s0304-3940(99)00762-4
  • Sayfa Sayıları: ss.71-74


The effect of a unilateral g-hydroxydopamine (6-OHDA) lesion of the left medial forebrain bundle and 3 weeks treatment with L-DOPA of normal and 6-OHDA lesioned rats on CB1r mRNA expression was investigated by in situ hybridization. A 6-OHDA lesion of nigrostriatal pathway alone, confirmed by the loss of nigral tyrosine hydroxylase mRNA, did not alter CB1r mRNA levels in the dopamine depleted striatum. Similarly, chronic L-DOPA treatment of normal rats had no effect on striatal CB1r mRNA expression. In contrast, chronic L-DOPA treatment of 6-OHDA-lesioned rats significantly increased CB1r mRNA expression in the denervated striatum. These results suggest that the CB1r activity may be altered by L-DOPA's action and this may be related to the treatment of Parkinson's disease. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.