May toxicity of amiodarone be prevented by antioxidants? A cell-culture study


Durukan A. B. , ERDEM B. , Durukan E., SEVİM H. , Karaduman T. , Gurbuz H. A. , ...More

JOURNAL OF CARDIOTHORACIC SURGERY, vol.7, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 7
  • Publication Date: 2012
  • Doi Number: 10.1186/1749-8090-7-61
  • Title of Journal : JOURNAL OF CARDIOTHORACIC SURGERY

Abstract

Background: Atrial Fibrillation is the most common arrhythmia encountered following cardiac surgery. The most commonly administered drug used in treatment and prophylaxis is amiodarone which has several toxic effects on major organ functions. There are few clinical data concerning prevention of toxic effects and there is no routinely suggested agent. The aim of this study is to document the cytotoxic effects of amiodarone on cell culture media and compare the cytoprotective effects of commonly used antioxidant agents.