Purpose: To investigate the relationship between neonatal birth weight (NBW) and intrapartum maternal mean platelet volume (MPV). Materials and Methods: A total of 650 women who had a live birth at the Etlik Zubeyde Hamm Women's Health Education and Research Hospital in Ankara were divided into three groups according to the babies' birth weight adjusted for gestational week: 145 delivered small for gestational age (SGA) (< 10th percentile), 363 delivered appropriate for gestational age (AGA) (10-90th percentile), and 142 delivered large for gestational age (LGA) babies (> 90th percentile). Maternal MPV value of the women were taken into account together with demographic values, body mass index (BMI), and gestational age at delivery and birth weight. Results: MPV was found to be significantly higher in the mothers of LGAbabies (9.6 +/- 1.11) in comparison to SGA (9.38 +/- 1.03) andAGA (9.36 +/- 1.09) babies in the statistical analysis (p = 0.009). More than 9.65 fL value of intrapartum maternal MPV was associated with LGA. Conclusion: MPV was increased in the intrapartum period in women who delivered LGA babies.