Fractional Wavelet Transform and Chemometric Calibrations for the Simultaneous Determination of Amlodipine and Valsartan in Their Complex Mixture


International Workshops on New Trends in Science and Technology (NTST 08)/ Fractional Differentiation and its Applications (FDA08), Ankara, Turkey, 01 November 2008, pp.333-335 identifier

  • Publication Type: Conference Paper / Full Text
  • Volume:
  • Doi Number: 10.1007/978-90-481-3293-5_29
  • City: Ankara
  • Country: Turkey
  • Page Numbers: pp.333-335
  • Hacettepe University Affiliated: Yes


Fractional wavelet transform (FWT) was applied to the original absorption spectra of amlodipine valsartan mixture. The determination of amlodipine and valsartan in their commercial tablets in the presence of inactive ingredients was carried out by using a full-spectrum multivariate calibration method, partial least squares (PLS). Two PLS algorithms (PLS1 and PLS2) based on different pre-processing methodologies were used for a comparison between the predicted concentrations of amlodipine and valsartan in samples. The experimental calibration matrix corresponding to the concentrations levels between 1.08-17.27 mu g/mL for amlodipine and 3.00-35.00 mu g/mL for valsartan. A recovery study with the synthetic mixtures was carried out and the obtained results were highly satisfactory. The predicted concentration results obtained by applying the proposed PLS calibrations to real samples were satisfactory in all cases.