Evidence for the Control of Aggrecanases by Insulin and Glucose in Alzheimer's Disease


Akyol S., Ugurcu V., ÇAKMAK Ö., Altuntas A., Yukselten Y., AKYOL Ö. , ...Daha Fazla

KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY, cilt.24, sa.4, ss.323-332, 2014 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 24 Konu: 4
  • Basım Tarihi: 2014
  • Doi Numarası: 10.5455/bcp.20140905124459
  • Dergi Adı: KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY
  • Sayfa Sayıları: ss.323-332

Özet

Objective: Alzheimer's disease (AD) is a progressive and irreversible central nervous system disease, which slowly destroys cognitive skills and memory, and eventually even the ability to handle the simplest tasks. The initiation and progression of AD is a poorly understood complex process. Here, we have investigated possible biological mechanisms that could be responsible for the increased risk for diminished brain function associated with diabetes in AD.