Evidence for the Control of Aggrecanases by Insulin and Glucose in Alzheimer's Disease

Akyol S., Ugurcu V., ÇAKMAK Ö., Altuntas A., Yukselten Y., AKYOL Ö., ...More

KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY, vol.24, no.4, pp.323-332, 2014 (SCI-Expanded) identifier identifier


Objective: Alzheimer's disease (AD) is a progressive and irreversible central nervous system disease, which slowly destroys cognitive skills and memory, and eventually even the ability to handle the simplest tasks. The initiation and progression of AD is a poorly understood complex process. Here, we have investigated possible biological mechanisms that could be responsible for the increased risk for diminished brain function associated with diabetes in AD.