The protective effect of taurine against gentamicin-induced acute tubular necrosis in rats

Erdem, AYŞEN; Gundogan, NU; Usubutun, A; Kilinc, K; Erdem, SR; Kara, A; Bozkurt, ATİLLA

doi:10.1093/ndt/15.8.1175

The protective effect of taurine against gentamicin-induced acute tubular necrosis in rats

Erdem A., Gundogan N., Usubutun A., Kilinc K., Erdem S., Kara A., ...More

NEPHROLOGY DIALYSIS TRANSPLANTATION, vol.15, no.8, pp.1175-1182, 2000 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 15 Issue: 8
Publication Date: 2000
Doi Number: 10.1093/ndt/15.8.1175
Journal Name: NEPHROLOGY DIALYSIS TRANSPLANTATION
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1175-1182
Open Archive Collection: AVESIS Open Access Collection
Hacettepe University Affiliated: Yes

Abstract

Background. Taurine, which is the major intracellular free beta-amino acid, is known to be an endogenous antioxidant and a membrane-stabilizing agent. In this study, we wished to know whether taurine altered the concentration of gentamicin in kidney tissue and could protect against gentamicin-induced acute proximal tubular injury.