The protective effect of taurine against gentamicin-induced acute tubular necrosis in rats

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Erdem A., Gundogan N., Usubutun A., Kilinc K., Erdem S., Kara A., ...More

NEPHROLOGY DIALYSIS TRANSPLANTATION, vol.15, no.8, pp.1175-1182, 2000 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 8
  • Publication Date: 2000
  • Doi Number: 10.1093/ndt/15.8.1175
  • Journal Name: NEPHROLOGY DIALYSIS TRANSPLANTATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1175-1182
  • Hacettepe University Affiliated: Yes

Abstract

Background. Taurine, which is the major intracellular free beta-amino acid, is known to be an endogenous antioxidant and a membrane-stabilizing agent. In this study, we wished to know whether taurine altered the concentration of gentamicin in kidney tissue and could protect against gentamicin-induced acute proximal tubular injury.