The protective effect of taurine against gentamicin-induced acute tubular necrosis in rats


Erdem A. , Gundogan N., Usubutun A., Kilinc K., Erdem S., Kara A., ...More

NEPHROLOGY DIALYSIS TRANSPLANTATION, vol.15, no.8, pp.1175-1182, 2000 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 8
  • Publication Date: 2000
  • Doi Number: 10.1093/ndt/15.8.1175
  • Title of Journal : NEPHROLOGY DIALYSIS TRANSPLANTATION
  • Page Numbers: pp.1175-1182

Abstract

Background. Taurine, which is the major intracellular free beta-amino acid, is known to be an endogenous antioxidant and a membrane-stabilizing agent. In this study, we wished to know whether taurine altered the concentration of gentamicin in kidney tissue and could protect against gentamicin-induced acute proximal tubular injury.